1999-2000 Academic All-State Nominees
Girls
| NAME | SCHOOL | COACH | ||
| Courtney Brent | Nixa | Randy Towe | ||
| Mary Cowherd | Chillicothe | Tom Hayob | ||
| Jennifer Easton | Maryville | Randall Cook | ||
| Amy Fecke | Lamonte R-IV | Jeff Backe | ||
| Lindsay Gaither | Canton | Andy Anderson | ||
| Jennifer Green | Eldon | Rick White | ||
| Micah Gunter | Knox County | Bill Dorethy | ||
| Lesley Hawley | Glendale | Tina Robbins | ||
| Carrie Highfill | Clever | Shawn Poyser | ||
| Holly Holtman | Jefferson | Don Edwards | ||
| Lindsey Jackson | Norwood | Donnie Forrest | ||
| Cassie Jarvis | Willard | Joan Hartley | ||
| Jamie Dawn Knierim | Tarkio | Doug Kingery | ||
| Jennifer Lindsey | Van Buren | Don Mabry | ||
| Taran May | Chillicothe | Tom Hayob | ||
| Jennifer McDonnell | Archie | Troy Schulte | ||
| Emily Neilsen | Nerinx Hall | Carol Ann Brown | ||
| Thandeka Ngwenyama | Holden | Heath Waters | ||
| Katie Scherer | Crest Ridge | Shawn Bigler | ||
| Shawna Sing | Plato | Gary Amos | ||
| Allison Spidle | Gallatin | Rick Lin | ||
| Kelly Steinman | Vienna | Mick Byrd | ||
| Sara Stratton | Glendale | Tina Robbins | ||
| Autumn Thomas | South Callaway | Randy Riddle | ||
| Kristin Walker | Pattonsburg | Troy Clawson | ||
| Bonnie Wheeler | Union Star | Derek Petty |